Main Article Content

Abstract

Pulmonary tuberculosis (TB) is an infectious disease that attacks the lungs and is caused by the bacterium Mycobacterium tuberculosis. The GeneXpert RT-PCR examination (Xpert MTB / RIF) is a development of a diagnostic tool that can automatically detect the presence of Mycobacterium tuberculosis (MTB) by molecular examination and can be used to detect MTB resistance to rifampicin. Erythrocyte sedimentation rate (ESR) is a test used to determine the rate at which erythrocytes settle in the blood. The purpose of this study was to determine the relationship between GeneXpert RT-PCR results and ESR in suspected tuberculosis patients. This research uses a cross-sectional study. The sample used in this study were 56 new suspected TB patients who had never been treated for ATD and underwent GeneXpert RT-PCR examination. Sampling was carried out by purposive sampling with the TCM Rif Sen group and negative results. A total of 27 patients (96.4%) with Rif Sen's GeneXpert RT-PCR results had high ESR values. 15 patients (53.6%) with negative GeneXpert RT-PCR results had normal ESR values. The results of the Chi Square test (X2) show that p-value = 0.000 OR = 0.032. There is a significant relationship between GeneXpert and ESR values ​​in suspected tuberculosis

Keywords

GeneXpert Erythrocyte Sedimentation Rate Rif Sen Tuberculosis

Article Details

How to Cite
Listiyowati, T., Wardani, D., Sudarsono, T., & Wijayanti, L. (2023). Relationship Between Results of Genexpert RT-PCR and Erythrocyte Sedimentation Rate in Suspected Tuberculosis Patients. Jurnal Ilmu Dan Teknologi Kesehatan, 10(2), 259-267. https://doi.org/10.32668/jitek.v10i2.1078

References

    Alamlih, L. et al. (2020) ‘Hematologic Characteristics of Patients with Active Pulmonary, Extra-Pulmonary and Disseminated Tuberculosis: A Study of over Six Hundred Patients’, Journal of Tuberculosis Research, 08(02), pp. 33–41. doi: 10.4236/jtr.2020.82004.

    Boehme, C. C. et al. (2011) 'Feasibility, diagnostic accuracy, and effectiveness of decentralized use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: A multicentre implementation study', The Lancet, 377(9776), pp. 1495–1505. doi: 10.1016/S0140-6736(11)60438-8.

    Costantini, L., Marando, M. and Gianella, P. (2020) ‘Long-Term GeneXpert Positivity after Treatment for Pulmonary Tuberculosis’, European Journal of Case Reports in Internal Medicine, 2021(8), p. 12890. doi: 10.12890/2020.

    Dewi, A. A. I. S., Andrika, P. and Artana, I. B. (2020) ‘Gambaran Karateristik Pasien Tuberculosis Di Poliklinik Paru Rsup Sanglah Denpasar’, Jurnal Medika Udayana, Vol. 9 No.6, 9(1), pp. 22–27. Available at: https://ojs.unud.ac.id/index.php/eum/article/view/60533/35024.

    Dina, D., Zaini, M. and Yahya, Y. (2019) ‘Gambaran Pemeriksaaan Hapusan Darah Tepi Diffcount (Sel Limfosit) Pada Penderita TBC Di Puskesmas Kelayan Timur Banjarmasin’, Jurnal Kajian Ilmiah Kesehatan dan …, 1(2), pp. 34–38. Available at: http://jurnal.polanka.ac.id/index.php/JKIKT/article/view/8.

    DinkesProv Jateng (2021) Profil Kesehatan Jawa Tengah Tahun 2021. Semarang.

    Elbrolosy, A. M. et al. (2021) ‘Diagnostic utility of GeneXpert MTB/RIF assay versus conventional methods for diagnosis of pulmonary and extra-pulmonary tuberculosis’, BMC Microbiology, 21(1), pp. 1–10. doi: 10.1186/s12866-021-02210-5.

    Hasnawati (2018) ‘Pengaruh Infeksi Mycobacterium tuberculosis Terhadap Nilai Laju Endap Darah Penderita Tuberculosis Paru di Balai Besar Kesehatan Paru Masyarakat’, Jurnal Media Analis Kesehatan, 1(1), pp. 8–13. doi: 10.32382/mak.v1i1.119.

    Hidriyah, S., Rahmita, M. and Trisna, C. (2018) ‘Perbandingan Nilai Laju Endap Darah (Led) Antara Metode Westergren Dengan Metode Mikro Esr Pada Penderita Tuberkulosis

    Paru’, Jurnal Medikes (Media Informasi Kesehatan), 5(2), pp. 182–191. doi: 10.36743/medikes.v5i2.59.

    Kasih, K. N. and Sulastina, N. A. (2019) ‘Analisis Laju Endap Darah Pada Pasien Tuberkulosis Paru’, Jurnal ’Aisyiyah Medika, 4(1), pp. 44–52. doi: 10.36729/jam.v4i1.232.

    Kemenkes (2022) Jumlah Kasus TB Tahun 2000-2022, Kementerian Kesehatan. Available at: https://tbindonesia.or.id/pustaka-tbc/dashboard-tb/.

    Kouassi, K. N. guessa. et al. (2016) ‘Genotyping of mutations detected with GeneXpert’, International Journal of Mycobacteriology, 5(2), pp. 142–147. doi: 10.1016/j.ijmyco.2016.01.001.

    Laily, D. W., Rombot, D. V and Lampus, B. S. (2015) ‘Karakteristik Pasien Tuberkulosis Paru Di Puskesmas Tuminting Manado’, Jurnal Kedokteran dan Tropik, 3(1), pp. 1–5.

    Naim, N. (2019) ‘Result Analysis of Erythrocyte Sedimentation Rate (ESR) For Tuberculosis (TB) Patient with Anti-Tuberculosis Drug’, International Journal of Science and Healthcare Research (www.ijshr.com), 4(2), pp. 143–148. Available at: www.ijshr.com.

    Naim, N. and Dewi, N. U. (2018) ‘Performa Tes Cepat Molekuler Dalam Diagnosa Tuberkulosis Di Balai Besar Kesehatan Paru Masyarakat Makassar’, Jurnal Media Analis Kesehatan, 9(2), pp. 113–122. doi: 10.32382/mak.v9i2.678.

    Nugraha, G. and Badrawi, I. (2018) Pedoman Teknik Pemeriksaan Laboratorium Klinik, Trans Info Media. Available at: www.transinfotim.blogspot.com.

    Permatasari, S. et al. (2021) ‘Validitas Metode Real Time PCR GeneXpert pada Suspek TB Paru BTA Negatif di RSUD Dr. Doris Sylvanus’, Jurnal Surya Medika, 7(1), pp. 88–93. doi: 10.33084/jsm.v7i1.2037.

    Qo’imah, A. N. et al. (2022) ‘Comparison of TSH Levels Pulmonary Tuberculosis Patients at The Phase 0 and 6 Months Treatment’, Jurnal Ilmu dan Teknologi Kesehatan, 10(1), pp. 99–107. doi: 10.32668/jitek.v10i1.910.

    Restrepo, B. I. (2018) ‘Diabetes and tuberculosis’, Understanding the Host Immune Response Against Mycobacterium tuberculosis Infection, (9), pp. 1–21. doi: 10.1007/978-3-319-97367-8_1.

    Rizqiya, R. N., Wuryaningsih, E. W. and Deviantony, F. (2021) ‘Hubungan Stigma Masyarakat Dengan Kepatuhan Minum Obat Pasien Tb Paru Di Puskesmas Puhjarak Kecamatan Plemahan Kabupaten Kediri’, Jurnal Ilmiah Kesehatan Keperawatan, 17(1), p. 66. doi: 10.26753/jikk.v17i1.511.

    Sasikumar, C. et al. (2020) ‘The role of genexpert in the diagnosis of mycobacterium tuberculosis’, Advances in Respiratory Medicine, 88(3), pp. 184–188. doi: 10.5603/ARM.2020.0102.

    Solanki, A. M. et al. (2020) ‘Sensitivity and Specificity of Gene Xpert in the Diagnosis of Spinal Tuberculosis: A Prospective Controlled Clinical Study’, Global Spine Journal, 10(5), pp. 553–558. doi: 10.1177/2192568219858310.

    Sorsa, A. (2020) ‘The diagnostic performance of chest-x-ray and erythrocyte sedimentation rate in comparison with genexpert® for tuberculosis case notification among patients living with human immunodeficiency virus in a resource-limited setting: A cross-sectional study’, Risk Management and Healthcare Policy, 13, pp. 1639–1646. doi:

    2147/RMHP.S264447.

    Sulochana, S. et al. (2022) ‘Clinical Significance of Erythrocyte Sedimentation Rate in Tuberculosis’, Research Journal of Pharmacy and Technology, 15(1), pp. 245–249. doi: 10.52711/0974-360X.2022.00040.

    Utami, P. R. et al. (2021) ‘Pemeriksaan GeneXpert Terhadap Tingkat Positivitas Pemeriksaan Basil Tahan Asam (BTA) Metode Ziehl Neelsen Pada Penderita Suspek TB Paru’, Jurnal Kesehatan Perintis (Perintis’s Health Journal), 8(1), pp. 82–90. doi: 10.33653/jkp.v8i1.598.

    WHO (2021) Global Tuberculosis Report 2021. 2021st edn. Jenewa: WHO.